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In a major upset, Democratic Congressman William Jefferson has lost his seat in LA-2, according to the AP.
This is the 5th Democratic seat the Republicans picked up this year, and puts the overall House net gain back at 20 seats.
Democrats can still pick up 1 more seat, in OH-15. (This assumes Democrat Tom Perriello stays ahead in the recount in VA-5).
Update on OH-15:
At noon, about 40 workers at the Franklin County Board of Elections began cutting open the envelopes holding nearly 24,000 provisional ballots that will decide the outcome of the country's closest congressional race.
Results are expected to be made public Sunday night, elections officials said.